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KMID : 0043320140370080978
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Archives of Pharmacal Research
2014 Volume.37 No. 8 p.978 ~ p.982
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Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65
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Sun Xinhua
Kong Xianglan
Gao Huquan
Zhu Tianjiao
Wu Guangwei
Gu Qianqun
Li Dehai
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Abstract
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Two new meroterpenoids, arisugacins I (1) and J (2), together with five known meroterpenoids including arisugacin B (3), arisugacin F (4), arisugacin G (5), territrem B (6) and territrem C (7) were isolated from an endophytic fungus Penicillium sp. SXH-65. Their structures were determined by extensive spectroscopic experiments and comparison with literature data. Their cytotoxicities were evaluated against Hela, HL-60 and K562 cell lines, and only 3 and 4 exhibited weak cytotoxicities against Hela, HL-60 and K562 cell lines with IC50 values ranging from 24 to 60 μM.
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KEYWORD
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Meroterpenoid, Arisugacin, Penicillium sp., Secondary metabolites, Cytotoxicity
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